ABO Blood Groups and Disease

AMost geneticists beliezve that genetic factors are inzolv!ed in susceptibility and resistance to many "non-Mendelizing" human diseases. It seems, therefore, reasonable to look for disease associations among genetic polymorphisms, and a great deal of work has already been done with blood groups in this field. Dr. Vogel summarizes his extensive experience with this approach in thefirst annotation. Dr. IViener has been an outspoken critic of such approaches and points out zarious fallacies in a second annotation. The juxtaposition of contrasting assessments may help readers to form their own opinion. Hopefully, publication of such annotations might lead to more conculsive research studies in the future.